macAB is induced upon exposure to H 2O 2 and is critical for survival of Salmonella enterica serovar Typhimurium in the presence of peroxide. We demonstrate that macAB plays a role in the detoxification of reactive oxygen species (ROS), compounds that salmonellae are exposed to at various stages of infection.
The molecular mechanism of this link between macAB and infection is unclear. The macrolide-specific pump MacAB, the only ABC-type drug efflux pump in Salmonella, has previously been linked to virulence in mice. Multidrug efflux pumps are integral membrane proteins known to actively excrete antibiotics.
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